University Medical Center Utrecht (UMC Utrecht) 
Utrecht, Netherlands İlan Özeti
UMC Utrecht seeks a Postdoctoral Researcher to discover and validate molecular biomarkers for amyotrophic lateral sclerosis (ALS). Based in the Department of Neurology and Neurosurgery, you will join the ALS Center Netherlands and collaborate with Leuven on the PLUS-ALS project. Responsibilities include identifying biomarker candidates from omics data, developing validation workflows, and translating findings into clinical panels using techniques like ECL and ELISA. The role requires a PhD in molecular biology or related fields, with experience in proteomics and immunoassays. You will work within an international multidisciplinary team, accessing extensive patient cohorts and biobanks. The position offers a gross monthly salary between EUR 3,724 and EUR 5,867, based on full-time employment. Benefits include an eight percent holiday allowance, an eight-point-three percent year-end bonus, pension contributions, and public transport reimbursement. The initial contract is for one year, with potential extension aligned with the five-year PLUS-ALS duration.
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Proje Açıklaması
As a postdoctoral researcher, you will be responsible for designing and independently conducting scientific research focused on the discovery and validation of molecular biomarkers for amyotrophic lateral sclerosis (ALS). Your responsibilities will include:
- Identifying new biomarker candidates from various types of omics data, including Olink and NULISA.
- Developing robust and efficient validation workflows.
- Translating promising biomarkers into panels suitable for clinical use.
- Performing laboratory research using techniques such as ECL, ELISA, western blotting, and related quantitative analytical methods.
- Collaborating with researchers in Utrecht and Leuven and regularly discussing research progress and findings.
- Analyzing research data and writing up results with statistical support from experienced methodologists.You will join the Department of Neurology and Neurosurgery at UMC Utrecht. The department conducts internationally leading research into neuromuscular disorders, including ALS and spinal muscular atrophy (SMA).You will be part of the ALS Center Netherlands and work on PLUS-ALS, a collaboration between the ALS centers in Utrecht and Leuven. The project aims to accelerate the development of ALS treatments through an innovative biomarker platform. You will have access to extensive, well-characterized patient cohorts and biobanks at both locations.You will work in an international team of researchers, clinicians, and methodologists. You will also collaborate with pharmaceutical partners through the TRICALS network. This collaboration allows you to combine scientific research with knowledge that can contribute to the development of new treatments for people living with ALS.
- You hold a PhD or are close to completing one in molecular biology, biochemistry, biomedical sciences, or a related field.
- You have demonstrable experience in proteomics, immunoassays, and/or biomarker validation.
- You are interested in translational research and applying research findings in clinical practice.
- Experience with amyotrophic lateral sclerosis (ALS) or other neurodegenerative disorders is an advantage.
- You can work independently and collaborate effectively within a multidisciplinary, international team.
- You have excellent written and spoken English skills.
- A salary between € 3.724 en € 5.867 gross per month (salary scale 10), based on full-time employment (36 hours).
- An employment contract for one year, with the possibility of an extension for the duration of PLUS-ALS (five years).
- Year-end bonus of 8.3% and holiday allowance of 8%.
- Pension insurance with ABP. We take care of approximately 70% of the monthly contribution.
- 100% public transport reimbursement. Are you coming on foot, by bike or by car? You will then receive a reimbursement of € 0.18 per km (by car up to a max. of 40 km one way).
- Possibilities to develop yourself personally and professionally.
- The option to select additional employment benefits in exchange for gross salary, such as purchasing a bicycle and memberships.
