PhD candidate | Drug delivery across the blood-brain barrier in brain disorder

About your role

You will develop and apply advanced human in vitro models to study drug delivery across the blood-brain barrier. You will:

• compare the therapeutic potential of natural and synthetic nanocarriers;
• work with hiPSC-derived cortical brain organoids and human blood-brain barrier models;
• investigate neurovascular interactions and the delivery of therapeutic compounds to the brain;
• contribute to applications in disease modelling, therapeutic target discovery and drug screening;
• collaborate with researchers from Amsterdam UMC and Locsense within this interdisciplinary public-private partnership.
  About you
  We are looking for a highly motivated and enthusiastic researcher with an interest in drug delivery, human in vitro models and neurological diseases. You have:
• a Master’s degree in neuroscience, biomedical sciences or a related field;
• an interest in in vitro modelling, nanoparticle technologies, blood-brain barrier biology and neurodegenerative diseases;
• experience with hiPSC culture and differentiation and/or in vitro blood-brain barrier models and brain organoids;
• experience with organ-on-chip, MEA or nanoparticle technologies is an advantage;
• excellent written and verbal communication skills in English, a proactive and flexible attitude, and the ability to work independently as well as collaboratively.
  Our offer
  
• You will be employed by Amsterdam UMC Research BV.
• A contract for 12 months, with the intention to extend for a total of four years. The Guideline PhD contract applies to this vacancy.
• Classification in salary scale OIO: € 3.217 to € 4.077 gross for full-time employment (depending on experience). In addition to a good basic salary, we offer 8.3% end-of-year bonus. Calculate your net salary here.
• Holiday hours: 194.4 per year for full time and a possibility to save additional hours.
• 100% reimbursement for public transport travel costs. If you travel by foot, bicycle, or car, a mileage allowance of €0.21 per km applies (up to a maximum of 40 km one way by car).
• Do you prefer walking or cycling? Take advantage of our good bike scheme.
• Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.Watch this video with more information about joining Amsterdam UMC Research BV.